Stimulation of ROS production by RRTF1 might be important for a rapid and transient establishment of local ROS maxima to induce appropriate downstream responses (Wang and Higgins, 2005)
However, it has notable downsides: Cognitive side effects (brain fog, memory issues, difficulty concentrating) Can cause depression and mood instability Often leads to significant tingling sensations in the extremities Not as effective as newer weight-loss drugs Metformin Metformin is primarily used for type 2 diabetes but is sometimes prescribed off-label for weight loss due to its effects on insulin sensitivity and appetite
The mechanism points elsewhere
Slowed gastric emptying creates a sensation of fullness, but it can also lead to side effects such as bloating, nausea, heartburn, and general discomfort
Studies published between 2019 and 2025 investigating VR-based cognitive interventions in individuals diagnosed with SCD or MCI were identified through searches in PubMed, Scopus, Embase, and Web of Science